The US central bank is widely expected on Wednesday to raise its main interest rate for the tenth consecutive month in the continuing battle against inflation, despite worries over the impact on bank balance sheets.
While higher interest rates are generally good news for bank earnings, the Federal Reserve’s aggressive pace of rate rises in just over a year has also made lenders’ bondholdings less valuable.
A crisis of confidence since March has seen three US lenders fail.
The latest, First Republic, saw the majority of its assets bought by JPMorgan Chase ahead of the market open on Monday.
Shares in many other top regional lenders have suffered since.
It is the pressing issue for Fed chair Jay Powell, who is coming under mounting pressure to signal that the period of rate increases is over despite inflation proving more stubborn to bring down than anticipated.
A 0.25 percentage point rise in its benchmark target rate would take it to its highest level since 2007 of between 5%-5.25%.
Mr Powell will also be mindful that too high a rate risks tipping the economy into recession.
That could be partly driven by a credit crunch due to the turmoil in the banking sector.
Market analysts suggested Mr Powell would be likely to face searching questions over the impact of rising rates on banks as the economy slows.
He is also likely to be asked about the state’s ability to support lenders in the wake of the bank failures to date.
Read more from Sky News:
Interest rate rises are supposed to bring down inflation but haven’t – so why are we paying more on mortgages?
City watchdog eyes listing shake-up to make London more attractive
Also on the minds of journalists will be the looming deadline for the US debt ceiling, with Mr Powell tipped to be asked about his contingencies should Congress fail to agree an extension risking a US default.
US Treasury secretary Janet Yellen has warned the government could run out of cash on 1 June without a deal.
The market will be eagerly awaiting any clear direction on whether the interest rate rises are over.
Susannah Streeter, head of money and markets at Hargreaves Lansdown, said ahead of Wednesday trading: “‘Caution is set to take centre stage ahead of the Fed’s interest rate decision later, as investors mull what’s ahead for the mighty US economy.
“Worries have ratcheted up again that a maelstrom of problems are lurking within regional banks and that there could be another breakage as interest rates are set to be hiked again.
“There was hardly a pause for breath after the JP Morgan takeover of First Republic Bank before fears rocked regional banking stocks yet again, with PacWest one of the biggest fallers, dropping by more than 30% at one point.
“The tide of concern is rising about the ailing health of regional US bank portfolios”, she warned.